| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-STAP2/BKS (391-403) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 49kDa band observed in Human Breast lysates (calculated MW of 49.6kDa according to NP_060190.2). Recommended concentration: 0.3-1µg/ml.IHC: Paraffin embedded Human Small I |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | STAP2 |
| Gene ID: | 55620 |
| Uniprot ID: | STAP2_HUMAN |
| Immunogen Region: | 391-403 |
| Accession Number: | NP_060190.2; NP_001013863.1 |
| Specificity: | This antibody is expected to recognize isoform 1 (NP_060190.2) and isoform 2 (NP_001013863.1). |
| Immunogen Sequence: | LQKKLEKRRALEH |
| Post Translational Modifications | Phosphorylated on tyrosine. Tyr-250 may be important for interaction with kinases. Phosphorylated by PTK6 at Tyr-250 modulates PTK6-mediated STAT3 activation. Tyr-22 and Tyr-322 appears to be phosphorylated by SRC. |
| Function | Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity. |
| Protein Name | Signal-Transducing Adaptor Protein 2Stap-2Breast Tumor Kinase SubstrateBrk Substrate |
| Database Links | Reactome: R-HSA-8849474Reactome: R-HSA-9707564 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Signal-Transducing Adaptor Protein 2 antibodyAnti-Stap-2 antibodyAnti-Breast Tumor Kinase Substrate antibodyAnti-Brk Substrate antibodyAnti-STAP2 antibodyAnti-BKS antibody |
Information sourced from Uniprot.org