| Post Translational Modifications | Phosphorylated. |
| Function | Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. |
| Protein Name | Cohesin Subunit Sa-3Scc3 Homolog 3Stromal Antigen 3Stromalin-3 |
| Database Links | Reactome: R-HSA-1221632 |
| Cellular Localisation | NucleusChromosomeCentromereAssociates With ChromatinIn Prophase I Stage Of MeiosisIt Is Found Along The Axial Elements Of Synaptonemal ComplexesIn Late-Pachytene-DiploteneThe Bulk Of Protein Dissociates From The Chromosome Arms Probably Because Of Phosphorylation By Plk1Except At CentromeresWhere Cohesin Complexes RemainIt However Remains Chromatin Associated At The Centromeres Up To Metaphase IDuring Anaphase IIt Probably Dissociates From CentromeresAllowing Chromosomes Segregation |
| Alternative Antibody Names | Anti-Cohesin Subunit Sa-3 antibodyAnti-Scc3 Homolog 3 antibodyAnti-Stromal Antigen 3 antibodyAnti-Stromalin-3 antibodyAnti-STAG3 antibody |
Information sourced from Uniprot.org
