| Post Translational Modifications | Autopolysialylated. |
| Function | Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an acceptor, such as N-linked oligosaccharides of glycoproteins and glycolipids through alpha-2,8-linkages. Forms oligosialic and polysialic acid on various sialylated N-acetyllactosamine oligosaccharides of glycoproteins, including FETUB N-glycans, a2-HS-glycoprotein (AHSG) and alpha 2,3-sialylated glycosphingolipids, such as alpha 2,3-sialylparagloboside and ganglioside GM3 and to a lesser extent NCAM1 N-glycans. However, it is much more specific to N-linked oligosaccharides of glycoproteins than glycosphingolipids. 2,3-sialylparagloboside serves as the best acceptor substrate among the glycolipids. alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-6S-D-GlcNAc and monosialyl and disialyl N-acetyllactosamines are the best acceptor substrates among glycoproteins. May plays critical role in the striatum by mediating the formation of disialylated and trisialylated terminal glycotopes on N- and O-glycans of specific striatal proteins, regulating their distribution in lipid rafts, affecting their interaction with other binding partners, and subsequently modulating striatal functions. |
| Protein Name | Alpha-N-Acetylneuraminate Alpha-2 -8-Sialyltransferase St8sia3Alpha-2 -8-Sialyltransferase 8cAlpha-2 -8-Sialyltransferase IiiGanglioside Gd3 Synthase St8sia3St8 Alpha-N-Acetyl-Neuraminide Alpha-2 -8-Sialyltransferase 3Sia-A2 -3-Gal-B1 -4-Glc-Nac-R -A2 -8-SialyltransferaseHst8sia IiiSialyltransferase 8cSiat8-CSialyltransferase St8sia IiiSt8siaiii |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-975577 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Alpha-N-Acetylneuraminate Alpha-2 -8-Sialyltransferase St8sia3 antibodyAnti-Alpha-2 -8-Sialyltransferase 8c antibodyAnti-Alpha-2 -8-Sialyltransferase Iii antibodyAnti-Ganglioside Gd3 Synthase St8sia3 antibodyAnti-St8 Alpha-N-Acetyl-Neuraminide Alpha-2 -8-Sialyltransferase 3 antibodyAnti-Sia-A2 -3-Gal-B1 -4-Glc-Nac-R -A2 -8-Sialyltransferase antibodyAnti-Hst8sia Iii antibodyAnti-Sialyltransferase 8c antibodyAnti-Siat8-C antibodyAnti-Sialyltransferase St8sia Iii antibodyAnti-St8siaiii antibodyAnti-ST8SIA3 antibodyAnti-SIAT8C antibody |
Information sourced from Uniprot.org
