Anti-SPINK5 antibody (895-1094) (STJ118916)

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STJ118916
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SPINK5
Gene ID: 11005
Uniprot ID: ISK5_HUMAN
Immunogen Region: 895-1094
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 895-1094 of human SPINK5 (NP_001121170.1).
Immunogen Sequence: ERKKKDEEKSSSKPSNNAKD QCRQVQNEAEDAKFRQPGRS LASVARMSTDECSEFRNYIR NNELICPRENDPVHGADGKF YTNKCYMCRAVFLTEALERA KLQEKPSHVRASQEEDSPDS FSSLDSEMCKDYRVLPRIGY LCPKDLKPVCGDDGQTYNNP CMLCHENLIRQTNTHIRSTG KCEESSTPGTTAASMPPSDE
Tissue Specificity Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate.
Post Translational Modifications Proteolytically processed by furin in individual domains (D1, D5, D6, D8 through D11, and D9 through D15) exhibiting various inhibitory potentials for multiple proteases.
Function Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin.
Protein Name Serine Protease Inhibitor Kazal-Type 5
Lympho-Epithelial Kazal-Type-Related Inhibitor
Lekti Cleaved Into - Hemofiltrate Peptide Hf6478 - Hemofiltrate Peptide Hf7665
Database Links Reactome: R-HSA-6809371
Reactome: R-HSA-9725554
Cellular Localisation Secreted
Alternative Antibody Names Anti-Serine Protease Inhibitor Kazal-Type 5 antibody
Anti-Lympho-Epithelial Kazal-Type-Related Inhibitor antibody
Anti-Lekti Cleaved Into - Hemofiltrate Peptide Hf6478 - Hemofiltrate Peptide Hf7665 antibody
Anti-SPINK5 antibody

Information sourced from Uniprot.org

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