| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SPINK5 (895-1094) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SPINK5 |
| Gene ID: |
11005 |
| Uniprot ID: |
ISK5_HUMAN |
| Immunogen Region: |
895-1094 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 895-1094 of human SPINK5 (NP_001121170.1). |
| Immunogen Sequence: |
ERKKKDEEKSSSKPSNNAKD QCRQVQNEAEDAKFRQPGRS LASVARMSTDECSEFRNYIR NNELICPRENDPVHGADGKF YTNKCYMCRAVFLTEALERA KLQEKPSHVRASQEEDSPDS FSSLDSEMCKDYRVLPRIGY LCPKDLKPVCGDDGQTYNNP CMLCHENLIRQTNTHIRSTG KCEESSTPGTTAASMPPSDE |
| Tissue Specificity | Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate. |
| Post Translational Modifications | Proteolytically processed by furin in individual domains (D1, D5, D6, D8 through D11, and D9 through D15) exhibiting various inhibitory potentials for multiple proteases. |
| Function | Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. |
| Protein Name | Serine Protease Inhibitor Kazal-Type 5Lympho-Epithelial Kazal-Type-Related InhibitorLekti Cleaved Into - Hemofiltrate Peptide Hf6478 - Hemofiltrate Peptide Hf7665 |
| Database Links | Reactome: R-HSA-6809371 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Serine Protease Inhibitor Kazal-Type 5 antibodyAnti-Lympho-Epithelial Kazal-Type-Related Inhibitor antibodyAnti-Lekti Cleaved Into - Hemofiltrate Peptide Hf6478 - Hemofiltrate Peptide Hf7665 antibodyAnti-SPINK5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
