| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SPG11 |
| Gene ID: | 80208 |
| Uniprot ID: | SPTCS_HUMAN |
| Immunogen Region: | 550-750 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 550-750 of human SPG11 (NP_079413.3). |
| Immunogen Sequence: | KSKENLFNPSSKSSVSDQFD HLSSHLYLRNVEELIPALDL LCSAIRESYSEPQSKHFSEQ LLNLTLSFLNNQIKELFIHT EELDEHLQKGVNILTSYINE LRTFMIKFPWKLTDAIDEYD VHENVPKVKESNIWKKLSFE EVIASAILNNKIPEAQTFFR IDSHSAQKLEELIGIGLNLV FDNLKKNNIKEASELLKNMG F |
| Tissue Specificity | Expressed in all structures of brain, with a high expression in cerebellum. Expressed in cortical projection neurons. |
| Function | May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. |
| Protein Name | SpatacsinColorectal Carcinoma-Associated ProteinSpastic Paraplegia 11 Protein |
| Cellular Localisation | CytoplasmCytosolNucleusCell ProjectionAxonDendriteMainly Cytoplasmic |
| Alternative Antibody Names | Anti-Spatacsin antibodyAnti-Colorectal Carcinoma-Associated Protein antibodyAnti-Spastic Paraplegia 11 Protein antibodyAnti-SPG11 antibodyAnti-KIAA1840 antibody |
Information sourced from Uniprot.org