Anti-SOCS2 antibody (1-198) (STJ11102834)

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STJ11102834

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SOCS2 (1-198) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SOCS2
Gene ID: 8835
Uniprot ID: SOCS2_HUMAN
Immunogen Region: 1-198
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human SOCS2 (NP_001257400.1).
Immunogen Sequence: MTLRCLEPSGNGGEGTRSQW GTAGSAEEPSPQAARLAKAL RELGQTGWYWGSMTVNEAKE KLKEAPEGTFLIRDSSHSDY LLTISVKTSAGPTNLRIEYQ DGKFRLDSIICVKSKLKQFD SVVHLIDYYVQMCKDKRTGP EAPRNGTVHLYLTKPLYTSA PSLQHLCRLTINKCTGAIWG LPLPTRLKDYLEEYKFQV
Tissue Specificity High expression in heart, placenta, lung, kidney and prostate. Predominantly expressed in pulmonary epithelia cells, specifically type II pneumocytes.
Post Translational Modifications Ubiquitinated.mediated by AREL1 and leading to its subsequent proteasomal degradation. Ubiquitination is dependent on its phosphorylation at Ser-52, by PKC. Ubiquitination is stimulated by LPS. Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteasomal degradation.
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Name Suppressor Of Cytokine Signaling 2
Socs-2
Cytokine-Inducible Sh2 Protein 2
Cis-2
Stat-Induced Stat Inhibitor 2
Ssi-2
Database Links Reactome: R-HSA-1266695
Reactome: R-HSA-8951664
Reactome: R-HSA-9706369
Reactome: R-HSA-982772
Alternative Antibody Names Anti-Suppressor Of Cytokine Signaling 2 antibody
Anti-Socs-2 antibody
Anti-Cytokine-Inducible Sh2 Protein 2 antibody
Anti-Cis-2 antibody
Anti-Stat-Induced Stat Inhibitor 2 antibody
Anti-Ssi-2 antibody
Anti-SOCS2 antibody
Anti-CIS2 antibody
Anti-SSI2 antibody
Anti-STATI2 antibody

Information sourced from Uniprot.org

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