| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SNX17 |
| Gene ID: | 9784 |
| Uniprot ID: | SNX17_HUMAN |
| Immunogen Region: | 1-270 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human SNX17 (NP_055563.1). |
| Immunogen Sequence: | MHFSIPETESRSGDSGGSAY VAYNIHVNGVLHCRVRYSQL LGLHEQLRKEYGANVLPAFP PKKLFSLTPAEVEQRREQLE KYMQAVRQDPLLGSSETFNS FLRRAQQETQQVPTEEVSLE VLLSNGQKVLVNVLTSDQTE DVLEAVAAKLDLPDDLIGYF SLFLVREKEDGAFSFVRKLQ EFELPYVSVTSLRSQEYKIV LRKSYWDSAYDDDVMENRVG LNLLYAQTVSDIERGWILV |
| Function | Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). |
| Protein Name | Sorting Nexin-17 |
| Cellular Localisation | CytoplasmEarly EndosomeCytoplasmic Vesicle MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Sorting Nexin-17 antibodyAnti-SNX17 antibodyAnti-KIAA0064 antibody |
Information sourced from Uniprot.org