| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SMPD4 (600-800) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SMPD4 |
| Gene ID: |
55627 |
| Uniprot ID: |
NSMA3_HUMAN |
| Immunogen Region: |
600-800 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 600-800 of human SMPD4 (NP_060421.2). |
| Immunogen Sequence: |
ITQAKHTAKSISDQCAESPA GHSFLSWLGFSSMDTNGSYT ANDLDEMGQDSVRKTDEYLE KALEYLRQIFRLSEAQLRQF TLALGTTQDENGKKQLPDCI VGEDGLILTPLGRYQIINGL RRFEIEYQGDPELQPIRSYE IASLVRTLFRLSSAINHRFA GQMAALCSRDDFLGSFCRYH LTEPGLASRHLLSPVGRRQV A |
| Tissue Specificity | Widely expressed, with highest levels in heart and skeletal muscle. Isoform 1: Expressed in skeletal muscle (at protein level). Isoform 2: Expressed in skeletal muscle but a lower levels than isoform 1 (at protein level). |
| Function | Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function. May sensitize cells to DNA damage-induced apoptosis. In skeletal muscle, mediates TNF-stimulated oxidant production. |
| Protein Name | Sphingomyelin Phosphodiesterase 4Neutral Sphingomyelinase 3Nsmase-3Nsmase3Neutral Sphingomyelinase Iii |
| Database Links | Reactome: R-HSA-1660662 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinGolgi Apparatus MembraneNucleus EnvelopeCell MembraneSarcolemma |
| Alternative Antibody Names | Anti-Sphingomyelin Phosphodiesterase 4 antibodyAnti-Neutral Sphingomyelinase 3 antibodyAnti-Nsmase-3 antibodyAnti-Nsmase3 antibodyAnti-Neutral Sphingomyelinase Iii antibodyAnti-SMPD4 antibodyAnti-KIAA1418 antibodyAnti-SKNY antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
