Name: Anti-SMPD4 antibody (600-800) (STJ117668)
SKU: STJ117668
Availability: InStock

Anti-SMPD4 antibody (600-800) (STJ117668)

SKU:

STJ117668

£112.50 - £524.50

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Host:	Rabbit
Applications:	WB/IF/ICC/ELISA
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality :	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification:	Affinity purification
Concentration:	Lot specific
Dilution Range:	WB:1:200-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	SMPD4
Gene ID:	55627
Uniprot ID:	NSMA3_HUMAN
Immunogen Region:	600-800
Specificity:	Recombinant fusion protein containing a sequence corresponding to amino acids 600-800 of human SMPD4 (NP_060421.2).
Immunogen Sequence:	ITQAKHTAKSISDQCAESPA GHSFLSWLGFSSMDTNGSYT ANDLDEMGQDSVRKTDEYLE KALEYLRQIFRLSEAQLRQF TLALGTTQDENGKKQLPDCI VGEDGLILTPLGRYQIINGL RRFEIEYQGDPELQPIRSYE IASLVRTLFRLSSAINHRFA GQMAALCSRDDFLGSFCRYH LTEPGLASRHLLSPVGRRQV A

Tissue Specificity	Widely expressed, with highest levels in heart and skeletal muscle. Isoform 1: Expressed in skeletal muscle (at protein level). Isoform 2: Expressed in skeletal muscle but a lower levels than isoform 1 (at protein level).
Function	Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function. May sensitize cells to DNA damage-induced apoptosis. In skeletal muscle, mediates TNF-stimulated oxidant production.
Protein Name	Sphingomyelin Phosphodiesterase 4 Neutral Sphingomyelinase 3 Nsmase-3 Nsmase3 Neutral Sphingomyelinase Iii
Database Links	Reactome: R-HSA-9840310
Cellular Localisation	Endoplasmic Reticulum Membrane Single-Pass Membrane Protein Golgi Apparatus Membrane Nucleus Envelope Cell Membrane Sarcolemma
Alternative Antibody Names	Anti-Sphingomyelin Phosphodiesterase 4 antibody Anti-Neutral Sphingomyelinase 3 antibody Anti-Nsmase-3 antibody Anti-Nsmase3 antibody Anti-Neutral Sphingomyelinase Iii antibody Anti-SMPD4 antibody Anti-KIAA1418 antibody Anti-SKNY antibody

Information sourced from Uniprot.org

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STJ11100892	Anti-SKI antibody (700-800) (STJ11100892)	Rabbit	Polyclonal	Human/Mouse/Rat	WB/ELISA
STJ11104474	Anti-AXIN2 antibody (700-800) (STJ11104474)	Rabbit	Polyclonal	Human	IF/ICC/ELISA
STJ27666	Anti-RPS6KA5 antibody (700-800) (STJ27666)	Rabbit	Polyclonal	Human/Mouse/Rat	WB/ELISA

Anti-SMPD4 antibody (600-800) (STJ117668)