| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SMG7 |
| Gene ID: | 9887 |
| Uniprot ID: | SMG7_HUMAN |
| Immunogen Region: | 1-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SMG7 (NP_963863.2). |
| Immunogen Sequence: | MSLQSAQYLRQAEVLKADMT DSKLGPAEVWTSRQALQDLY QKMLVTDLEYALDKKVEQDL WNHAFKNQITTLQGQAKNRA NPNRSEVQANLSLFLEAASG FYTQLLQELCTVFNVDLPCR VKSSQLGIISNKQTHTSAIV KPQSSSCSYICQHCLVHLGD IARYRNQTSQAESYYRHAAQ LVPSNGQPYNQLAILASSKG DHLTTIFYYCRSIAVKFPFP AASTNLQKALSKALESRDE |
| Function | Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. |
| Protein Name | Nonsense-Mediated Mrna Decay Factor Smg7Smg-7 HomologHsmg-7 |
| Database Links | Reactome: R-HSA-975957 |
| Cellular Localisation | CytoplasmNucleusPredominantly CytoplasmicAnd NuclearShuttles Between Nucleus And Cytoplasm |
| Alternative Antibody Names | Anti-Nonsense-Mediated Mrna Decay Factor Smg7 antibodyAnti-Smg-7 Homolog antibodyAnti-Hsmg-7 antibodyAnti-SMG7 antibodyAnti-C1orf16 antibodyAnti-EST1C antibodyAnti-KIAA0250 antibody |
Information sourced from Uniprot.org