| Post Translational Modifications | Phosphorylation by TBK1 is required to promote autophagosome maturation. Phosphorylated by ULK1. |
| Function | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro. Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates. In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes. |
| Protein Name | Guanine Nucleotide Exchange Protein Smcr8Smith-Magenis Syndrome Chromosomal Region Candidate Gene 8 Protein |
| Cellular Localisation | CytoplasmNucleusPresynapsePostsynapseLocalizes Mainly In The Cytoplasm |
| Alternative Antibody Names | Anti-Guanine Nucleotide Exchange Protein Smcr8 antibodyAnti-Smith-Magenis Syndrome Chromosomal Region Candidate Gene 8 Protein antibodyAnti-SMCR8 antibody |
Information sourced from Uniprot.org
