| Host: |
Mouse |
| Applications: |
WB/IHC-P |
| Reactivity: |
Pig/Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-SLP-76 is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
SLP-76/03 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2b |
| Formulation: |
Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Purification: |
Purified by protein-A affinity chromatography. |
| Concentration: |
1 mg/mL |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Immunogen: |
Bacterially expressed fusion protein representing amino acids 216-434 of human SLP76 with histidine tag |
| Background | SLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells, mast cells, neutrophils and platelets; B cells express its analog SLP65/BLNK (B cell linker protein). SLP76 is phosphorylated by Syk-family and Tec-family tyrosine kinases and couples them to the phosphorylation and activation of PLC-gamma. Via Gads or Grb2, SLP76 also associates with LAT adaptor by involvement of SLP76 proline-rich region. The SH2 domain of SLP76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk-mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
