Anti-SLP-76 antibody [SLP-76/03] (STJ16100296)

Anti-SLP-76 antibody [SLP-76/03] (STJ16100296)

SKU:
STJ16100296-01
€671.88
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: Mouse
Applications: WB/IHC-P
Reactivity: Pig/Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-SLP-76 is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality : Monoclonal
Clone ID : SLP-76/03
Conjugation: Unconjugated
Isotype: IgG2b
Formulation: Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Purification: Purified by protein-A affinity chromatography.
Concentration: 1 mg/mL
Storage Instruction: Store at 2-8°C upon receipt.
Immunogen: Bacterially expressed fusion protein representing amino acids 216-434 of human SLP76 with histidine tag
Background SLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells, mast cells, neutrophils and platelets; B cells express its analog SLP65/BLNK (B cell linker protein). SLP76 is phosphorylated by Syk-family and Tec-family tyrosine kinases and couples them to the phosphorylation and activation of PLC-gamma. Via Gads or Grb2, SLP76 also associates with LAT adaptor by involvement of SLP76 proline-rich region. The SH2 domain of SLP76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk-mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation.

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJ16101300 Anti-SLP-76 antibody (STJ16101300) Rabbit Polyclonal Human WB/IHC-P
STJ70040 Anti-BLNK/SLP-65 antibody (C-Term) (STJ70040) Goat Polyclonal Human/Mouse/Rat/Dog/Pig/Cow Pep-ELISA/WB/IF/FC
STJ115769 Anti-STX10 antibody (76-165) (STJ115769) Rabbit Polyclonal Human WB/ELISA
STJA0006678 Anti-FP588 antibody (26-76) (STJA0006678) Rabbit Polyclonal Human/Rat/Mouse WB
STJ118766 Anti-ACP5 antibody (76-325) (STJ118766) Rabbit Polyclonal Human/Mouse WB/ELISA
STJ29468 Anti-ETS2 antibody (76-469) (STJ29468) Rabbit Polyclonal Human/Mouse/Rat WB/IF/ICC/ELISA
STJ72330 Anti-NTN4 antibody (65-76) (STJ72330) Goat Polyclonal Human/Mouse/Dog/Cow Pep-ELISA/IHC
STJ29452 Anti-TRIAP1 antibody (1-76) (STJ29452) Rabbit Polyclonal Human/Mouse WB/ELISA
STJ28744 Anti-MXI1 antibody (76-295) (STJ28744) Rabbit Polyclonal Human/Mouse/Rat WB/ELISA
!