| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Slit homolog 2 protein is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLIT2 |
| Gene ID: | 9353 |
| Uniprot ID: | SLIT2_HUMAN |
| Specificity: | SLIT2 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Function | Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal cord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal cord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration. |
| Protein Name | Slit Homolog 2 Protein Slit-2 Cleaved Into - Slit Homolog 2 Protein N-Product - Slit Homolog 2 Protein C-Product |
| Database Links | Reactome: R-HSA-373752 Reactome: R-HSA-376176 Reactome: R-HSA-428540 Reactome: R-HSA-428542 Reactome: R-HSA-428543 Reactome: R-HSA-428890 Reactome: R-HSA-8985586 Reactome: R-HSA-9010553 Reactome: R-HSA-9830674 |
| Cellular Localisation | Secreted The C-Terminal Cleavage Protein Is More Diffusible Than The Larger N-Terminal Protein That Is More Tightly Cell Associated |
| Alternative Antibody Names | Anti-Slit Homolog 2 Protein antibody Anti-Slit-2 Cleaved Into - Slit Homolog 2 Protein N-Product - Slit Homolog 2 Protein C-Product antibody Anti-SLIT2 antibody Anti-SLIL3 antibody |
Information sourced from Uniprot.org