Function | Electroneutral Na(+) Li(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane. Uses the proton gradient/membrane potential to extrude sodium. Contributes to the regulation of intracellular pH and sodium homeostasis. Also able to mediate Na(+)/Li(+) antiporter activity in kidney. May play a physiological role in renal tubular function and blood pressure homeostasis. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells. Involved in sperm motility and fertility. It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not. |
Protein Name | Sodium/Hydrogen Exchanger 9b2Na(+/H(+ Exchanger Nha2Na(+/H(+ Exchanger-Like Domain-Containing Protein 2Nhe Domain-Containing Protein 2Sodium/Hydrogen Exchanger-Like Domain-Containing Protein 2Solute Carrier Family 9 Subfamily B Member 2 |
Database Links | Reactome: R-HSA-2672351 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMitochondrion MembraneEndosome MembraneRecycling Endosome MembraneCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneCell ProjectionCiliumFlagellum MembraneBasolateral Cell MembraneApical Cell MembraneStrong Colocalization With Lamp1 And Tcirg1 In OsteoclastsIn Beta-Cells Colocalizes With Rab4a And SypLocalizes To The Basolateral Membrane Of Polarized Osteoclasts |
Alternative Antibody Names | Anti-Sodium/Hydrogen Exchanger 9b2 antibodyAnti-Na(+/H(+ Exchanger Nha2 antibodyAnti-Na(+/H(+ Exchanger-Like Domain-Containing Protein 2 antibodyAnti-Nhe Domain-Containing Protein 2 antibodyAnti-Sodium/Hydrogen Exchanger-Like Domain-Containing Protein 2 antibodyAnti-Solute Carrier Family 9 Subfamily B Member 2 antibodyAnti-SLC9B2 antibodyAnti-NHA2 antibodyAnti-NHEDC2 antibody |
Information sourced from Uniprot.org