| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
SLC9A1 |
| Gene ID: |
6548 |
| Uniprot ID: |
SL9A1_HUMAN |
| Immunogen Region: |
500-701 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 500-701 of human SLC9A1 (NP_003038.2). |
| Immunogen Sequence: |
RPLVDLLAVKKKQETKRSIN EEIHTQFLDHLLTGIEDICG HYGHHHWKDKLNRFNKKYVK KCLIAGERSKEPQLIAFYHK MEMKQAIELVESGGMGKIPS AVSTVSMQNIHPKSLPSERI LPALSKDKEEEIRKILRNNL QKTRQRLRSYNRHTLVADPY EEAWNQMLLRRQKARQLEQK INNYLTVPAHKLDSPTMSRA RI |
| Tissue Specificity | Kidney and intestine. |
| Post Translational Modifications | O-glycosylated. Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1. Phosphorylation at Thr-779 increases SLC9A1 activity. Specifically dephosphorylated at Thr-779 by PPP3CA that negatively regulates SLC9A1 activity. Phosphorylation at Ser-648 by AKT1 reduces SLC9A1 binding to CALM1. Palmitoylated.may play a major role in SLC9A1 regulation. |
| Function | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry. Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li(+) and functions also as a Na(+)/Li(+) antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs. |
| Protein Name | Sodium/Hydrogen Exchanger 1ApnhNa(+/H(+ Antiporter - Amiloride-SensitiveNa(+/H(+ Exchanger 1Nhe-1Solute Carrier Family 9 Member 1 |
| Database Links | Reactome: R-HSA-2160916Reactome: R-HSA-425986 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneLocalized Basolaterally In Every Epithelial CellExcept In The Choroid Plexus Where Slc9a1 Is Expressed Luminally |
| Alternative Antibody Names | Anti-Sodium/Hydrogen Exchanger 1 antibodyAnti-Apnh antibodyAnti-Na(+/H(+ Antiporter - Amiloride-Sensitive antibodyAnti-Na(+/H(+ Exchanger 1 antibodyAnti-Nhe-1 antibodyAnti-Solute Carrier Family 9 Member 1 antibodyAnti-SLC9A1 antibodyAnti-APNH1 antibodyAnti-NHE1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
