| Tissue Specificity | Isoform 1: High expression in kidney. Very small expression in adrenal gland and lung. Isoform 3: High expression in kidney. Very small expression in brain and testis. Isoform 6: Ubiquitously expressed in all tissues examined except the kidney. |
| Function | Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine, the platinum-based drugs cisplatin and oxaliplatin or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney. Isoform 6: Non-functional protein. |
| Protein Name | Multidrug And Toxin Extrusion Protein 2Mate-2Hmate-2Kidney-Specific H(+/Organic Cation AntiporterSolute Carrier Family 47 Member 2 |
| Database Links | Reactome: R-HSA-425366 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneDetected In The Renal Urinary TubulesIsoform 6: Apical Cell MembraneLocalized At The Brush Border Membranes Of The Proximal Tubules |
| Alternative Antibody Names | Anti-Multidrug And Toxin Extrusion Protein 2 antibodyAnti-Mate-2 antibodyAnti-Hmate-2 antibodyAnti-Kidney-Specific H(+/Organic Cation Antiporter antibodyAnti-Solute Carrier Family 47 Member 2 antibodyAnti-SLC47A2 antibodyAnti-MATE2 antibody |
Information sourced from Uniprot.org
