| Tissue Specificity | Highly expressed in colon, also detected in prostate, trachea and lung. Isoform 3 is also expressed in colon but a lower levels. Isoform 3: Expressed in colon at low levels. |
| Post Translational Modifications | N-glycosylated.N-glycosylation of Asn-69, Asn-155 and Asn-393 is required for a proper thiamine pyrophosphate uptake. |
| Function | Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury. Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis. Isoform 3: Has also thiamine pyrophosphate transporter activity. |
| Protein Name | Choline Transporter-Like Protein 4Solute Carrier Family 44 Member 4Thiamine Pyrophosphate Transporter 1Htppt1 |
| Database Links | Reactome: R-HSA-1483191Reactome: R-HSA-425366 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinApical Cell Membrane |
| Alternative Antibody Names | Anti-Choline Transporter-Like Protein 4 antibodyAnti-Solute Carrier Family 44 Member 4 antibodyAnti-Thiamine Pyrophosphate Transporter 1 antibodyAnti-Htppt1 antibodyAnti-SLC44A4 antibodyAnti-C6orf29 antibodyAnti-CTL4 antibodyAnti-NG22 antibodyAnti-TPPT1 antibodyAnti-UNQ441 antibodyAnti-PRO874 antibody |
Information sourced from Uniprot.org
