| Tissue Specificity | Widely expressed. Highly and transiently expressed during the early stage of adipocyte differentiation. Strongly expressed in liver, preadipocyte, duodenum and jejunum, moderately in brain, heart, skeletal muscle, spleen, pancreas, kidney and white adipose cells. Expression is almost undetectable in lung, testis and brown adipose cells. Expressed by chondrocytes and pituitary cells. Isoform 1: More strongly expressed in brain. Isoform 2: More strongly expressed in liver, kidney and duodenum. |
| Post Translational Modifications | Ubiquitinated. Ubiquitination occurs upon iron depletion. The ubiquitinated form undergoes proteasomal degradation. N-glycosylated. N-glycosylation at Asn-100 is required for iron-regulated extraction of the transporter from membranes and subsequent proteasomal degradation. |
| Function | Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity. Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions. Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic. Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability. Modifies the activity of zinc-dependent phosphodiesterases, thereby indirectly regulating G protein-coupled receptor signaling pathways important for gluconeogenesis and chondrocyte differentiation. Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin. Through zinc cellular uptake also plays a role in the adaptation of cells to endoplasmic reticulum stress. Major manganese transporter of the basolateral membrane of intestinal epithelial cells, it plays a central role in manganese systemic homeostasis through intestinal manganese uptake. Also involved in manganese extracellular uptake by cells of the blood-brain barrier. May also play a role in manganese and zinc homeostasis participating in their elimination from the blood through the hepatobiliary excretion. Also functions in the extracellular uptake of free iron. May also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin. Plays a role in innate immunity by regulating the expression of cytokines by activated macrophages. |
| Protein Name | Metal Cation Symporter Zip14Factor For Adipocyte Differentiation 123Fad-123Solute Carrier Family 39 Member 14Zrt- And Irt-Like Protein 14Zip-14 |
| Database Links | Reactome: R-MMU-442380 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneBasolateral Cell MembraneEarly Endosome MembraneLate Endosome MembraneLysosome MembraneLocalized At The Basolateral Membrane Of EnterocytesEnriched At The Plasma Membrane Upon Glucose UptakeLocalized And Functional At Both Apical And Basolateral Membranes Of Microvascular Capillary Endothelial Cells That Constitute The Blood-Brain Barrier |
| Alternative Antibody Names | Anti-Metal Cation Symporter Zip14 antibodyAnti-Factor For Adipocyte Differentiation 123 antibodyAnti-Fad-123 antibodyAnti-Solute Carrier Family 39 Member 14 antibodyAnti-Zrt- And Irt-Like Protein 14 antibodyAnti-Zip-14 antibodyAnti-Slc39a14 antibodyAnti-Fad123 antibodyAnti-Kiaa0062 antibodyAnti-Zip14 antibody |
Information sourced from Uniprot.org
