| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
SLC30A8 |
| Gene ID: |
169026 |
| Uniprot ID: |
ZNT8_HUMAN |
| Immunogen Region: |
1-75 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-75 of human SLC30A8 (NP_776250.2). |
| Immunogen Sequence: |
MEFLERTYLVNDKAAKMYAF TLESVELQQKPVNKDQCPRE RPEELESGGMYHCHSGSKPT EKGANEYAYAKWKLC |
| Tissue Specificity | In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons.much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive. |
| Function | Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion. |
| Protein Name | Proton-Coupled Zinc Antiporter Slc30a8Solute Carrier Family 30 Member 8Zinc Transporter 8Znt-8 |
| Database Links | Reactome: R-HSA-264876Reactome: R-HSA-435368 |
| Cellular Localisation | Cytoplasmic VesicleSecretory Vesicle MembraneMulti-Pass Membrane ProteinCell MembraneAssociated With Insulin And Glucagon Secretory Granules |
| Alternative Antibody Names | Anti-Proton-Coupled Zinc Antiporter Slc30a8 antibodyAnti-Solute Carrier Family 30 Member 8 antibodyAnti-Zinc Transporter 8 antibodyAnti-Znt-8 antibodyAnti-SLC30A8 antibodyAnti-ZNT8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
