| Function | May mediate the import of long-chain fatty acids (LCFA) by facilitating their transport across cell membranes. Also catalyzes the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates. Mainly functions as a bile acyl-CoA synthetase catalyzing the activation of bile acids via ATP-dependent formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine. Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate ((25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate or THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids. |
| Protein Name | Long-Chain Fatty Acid Transport Protein 5Fatp-5Fatty Acid Transport Protein 5Bile Acid-Coa LigaseBa-Coa LigaseBalBile Acyl-Coa SynthetaseBacsCholate--Coa LigaseFatty-Acid-Coenzyme A Ligase - Very Long-Chain 3Long-Chain-Fatty-Acid--Coa LigaseSolute Carrier Family 27 Member 5Very Long-Chain Acyl-Coa Synthetase Homolog 2Vlcs-H2Vlcsh2Very Long-Chain Acyl-Coa Synthetase-Related ProteinVlacs-RelatedVlacsr |
| Database Links | Reactome: R-HSA-159418Reactome: R-HSA-193368Reactome: R-HSA-193775 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinMicrosomeCell Membrane |
| Alternative Antibody Names | Anti-Long-Chain Fatty Acid Transport Protein 5 antibodyAnti-Fatp-5 antibodyAnti-Fatty Acid Transport Protein 5 antibodyAnti-Bile Acid-Coa Ligase antibodyAnti-Ba-Coa Ligase antibodyAnti-Bal antibodyAnti-Bile Acyl-Coa Synthetase antibodyAnti-Bacs antibodyAnti-Cholate--Coa Ligase antibodyAnti-Fatty-Acid-Coenzyme A Ligase - Very Long-Chain 3 antibodyAnti-Long-Chain-Fatty-Acid--Coa Ligase antibodyAnti-Solute Carrier Family 27 Member 5 antibodyAnti-Very Long-Chain Acyl-Coa Synthetase Homolog 2 antibodyAnti-Vlcs-H2 antibodyAnti-Vlcsh2 antibodyAnti-Very Long-Chain Acyl-Coa Synthetase-Related Protein antibodyAnti-Vlacs-Related antibodyAnti-Vlacsr antibodyAnti-SLC27A5 antibodyAnti-ACSB antibodyAnti-ACSVL6 antibodyAnti-FACVL3 antibodyAnti-FATP5 antibody |
Information sourced from Uniprot.org
