| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC10A1 (244-349) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Slc10a1 |
| Gene ID: |
20493 |
| Uniprot ID: |
NTCP_MOUSE |
| Immunogen Region: |
244-349 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 244-349 of mouse SLC10A1 (O08705). |
| Immunogen Sequence: |
FRLNPSCRRTISMETGFQNV QLCSTILNVTFPPEVIGPLF FFPLLYMIFQLAEGLLFIII FRCYLKIKPQKDQTKITYKA AATEDATPAALEKGTHNGNN PPTQPG |
| Tissue Specificity | Isoform 1: Expressed in liver in higher amounts than isoform 2. Isoform 2: Expressed in liver in lower amounts than isoform 1. |
| Function | As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It is strictly dependent on the extracellular presence of sodium. It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate. Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation. |
| Protein Name | Hepatic Sodium/Bile Acid CotransporterNa(+/Bile Acid CotransporterNa(+/Taurocholate Transport ProteinSodium/Taurocholate Cotransporting PolypeptideNtcpSolute Carrier Family 10 Member 1Slc10a1 |
| Database Links | Reactome: R-MMU-159418 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Hepatic Sodium/Bile Acid Cotransporter antibodyAnti-Na(+/Bile Acid Cotransporter antibodyAnti-Na(+/Taurocholate Transport Protein antibodyAnti-Sodium/Taurocholate Cotransporting Polypeptide antibodyAnti-Ntcp antibodyAnti-Solute Carrier Family 10 Member 1 antibodyAnti-Slc10a1 antibodyAnti-Slc10a1 antibodyAnti-Ntcp antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
