| Short Description : | Rat monoclonal anti-SIGN-R1 for use in IHC-F, FC and FUNC in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC-F/FC/FUNC |
| Host: | Rat |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | ER-TR9 |
| Isotype: | IgM |
| Conjugation: | Unconjugated |
| Concentration: | 200 Mu g/mL |
| Formulation: | PBS with 0.1% BSA and 0.02% sodium azide |
| Storage Instruction: | Store at 2-8°C for up to 1-year, upon receipt. |
| Background | The monoclonal antibody ER-TR9 recognizes murine SIGN-related 1 (SIGN-R1). Mouse SIGN-R1,-a homolog of human DC-SIGN, is a 37 kDa type II transmembrane protein containing a single, C-terminal C-type lectin domain. SIGN-R1 is a specific marker for the identification of macrophage subpopulations present in the marginal zone of spleen (the so-called marginal zone macrophages (MZM) ) , in the lymph node medulla, and in the peritoneal cavity of some mouse strains. ER-TR9 does not react with macrophages in other regions of the spleen, such as CD169+ marginal metallophils and F4/80+ red pulp macrophages. In the spleen, the MZM function in trapping and clearance of blood-borne microbial antigens. SIGN-R1 mediates the uptake of encapsulated microbes, particularly through the recognition of microbial polysaccharides. Uptake of FITC-labeled dextran by macrophages can be blocked both in vivo and in vitro by the monoclonal antibody ER-TR9. Therefore, the monoclonal antibody ER-TR9 can be used to study the uptake of polysaccharides by macrophages. |
Information sourced from Uniprot.org
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