| Tissue Specificity | Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver. |
| Post Translational Modifications | Phosphorylated on tyrosine residues. |
| Function | Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation. |
| Protein Name | Sh2 Domain-Containing Protein 2aSh2 Domain-Containing Adapter ProteinT Cell-Specific Adapter ProteinTsadVegf Receptor-Associated Protein |
| Database Links | Reactome: R-HSA-4420097 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Sh2 Domain-Containing Protein 2a antibodyAnti-Sh2 Domain-Containing Adapter Protein antibodyAnti-T Cell-Specific Adapter Protein antibodyAnti-Tsad antibodyAnti-Vegf Receptor-Associated Protein antibodyAnti-SH2D2A antibodyAnti-SCAP antibodyAnti-TSAD antibodyAnti-VRAP antibody |
Information sourced from Uniprot.org
