Host: | Rabbit |
Applications: | WB/IF/ICC/ELISA |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | SH2D1A |
Gene ID: | 4068 |
Uniprot ID: | SH21A_HUMAN |
Immunogen Region: | 1-128 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human SH2D1A (NP_002342.1). |
Immunogen Sequence: | MDAVAVYHGKISRETGEKLL LATGLDGSYLLRDSESVPGV YCLCVLYHGYIYTYRVSQTE TGSWSAETAPGVHKRYFRKI KNLISAFQKPDQGIVIPLQY PVEKKSSARSTQGTTGIRED PDVCLKAP |
Tissue Specificity | Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T-lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis. |
Function | Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. |
Protein Name | Sh2 Domain-Containing Protein 1a Duncan Disease Sh2-Protein Signaling Lymphocytic Activation Molecule-Associated Protein Slam-Associated Protein T-Cell Signal Transduction Molecule Sap |
Database Links | Reactome: R-HSA-198933 |
Cellular Localisation | Cytoplasm |
Alternative Antibody Names | Anti-Sh2 Domain-Containing Protein 1a antibody Anti-Duncan Disease Sh2-Protein antibody Anti-Signaling Lymphocytic Activation Molecule-Associated Protein antibody Anti-Slam-Associated Protein antibody Anti-T-Cell Signal Transduction Molecule Sap antibody Anti-SH2D1A antibody Anti-DSHP antibody Anti-SAP antibody |
Information sourced from Uniprot.org