Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-SF3B5 (1-86) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | SF3B5 |
Gene ID: | 83443 |
Uniprot ID: | SF3B5_HUMAN |
Immunogen Region: | 1-86 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-86 of human SF3B5 (NP_112577.1). |
Immunogen Sequence: | MTDRYTIHSQLEHLQSKYIG TGHADTTKWEWLVNQHRDSY CSYMGHFDLLNYFAIAENES KARVRFNLMEKMLQPCGPPA DKPEEN |
Function | Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). |
Protein Name | Splicing Factor 3b Subunit 5 Sf3b5 Pre-Mrna-Splicing Factor Sf3b 10 Kda Subunit |
Database Links | Reactome: R-HSA-72163 Reactome: R-HSA-72165 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Splicing Factor 3b Subunit 5 antibody Anti-Sf3b5 antibody Anti-Pre-Mrna-Splicing Factor Sf3b 10 Kda Subunit antibody Anti-SF3B5 antibody Anti-SF3B10 antibody |
Information sourced from Uniprot.org