Host: |
Rabbit |
Applications: |
WB |
Reactivity: |
Human/Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-SETD4 (210-300) is suitable for use in Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:2000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
SETD4 |
Gene ID: |
54093 |
Uniprot ID: |
SETD4_HUMAN |
Immunogen Region: |
210-300 |
Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 210-300 of human SETD4 (NP_001007260). |
Immunogen Sequence: |
YLRPRQRECLSAEPDTCALA PYLDLLNHSPHVQVKAAFNE ETHSYEIRTTSRWRKHEEVF ICYGPHDNQRLFLEYGFVSV HNPHACVYVSR |
Function | Histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response. Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of pro-inflammatory cytokines IL6 and TNF-alpha. Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation. Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). |
Protein Name | Set Domain-Containing Protein 4 |
Cellular Localisation | CytoplasmCytosolNucleus |
Alternative Antibody Names | Anti-Set Domain-Containing Protein 4 antibodyAnti-SETD4 antibodyAnti-C21orf18 antibodyAnti-C21orf27 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance