| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SETD4 |
| Gene ID: | 54093 |
| Uniprot ID: | SETD4_HUMAN |
| Immunogen Region: | 210-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-300 of human SETD4 (NP_001007260). |
| Immunogen Sequence: | YLRPRQRECLSAEPDTCALA PYLDLLNHSPHVQVKAAFNE ETHSYEIRTTSRWRKHEEVF ICYGPHDNQRLFLEYGFVSV HNPHACVYVSR |
| Function | Histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response. Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of pro-inflammatory cytokines IL6 and TNF-alpha. Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation. Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). |
| Protein Name | Set Domain-Containing Protein 4 |
| Cellular Localisation | CytoplasmCytosolNucleus |
| Alternative Antibody Names | Anti-Set Domain-Containing Protein 4 antibodyAnti-SETD4 antibodyAnti-C21orf18 antibodyAnti-C21orf27 antibody |
Information sourced from Uniprot.org