| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SERPINI1 |
| Gene ID: | 5274 |
| Uniprot ID: | NEUS_HUMAN |
| Immunogen Region: | 181-410 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 181-410 of human SERPINI1 (NP_005016.1). |
| Immunogen Sequence: | INAVYFKGNWKSQFRPENTR TFSFTKDDESEVQIPMMYQQ GEFYYGEFSDGSNEAGGIYQ VLEIPYEGDEISMMLVLSRQ EVPLATLEPLVKAQLVEEWA NSVKKQKVEVYLPRFTVEQE IDLKDVLKALGITEIFIKDA NLTGLSDNKEIFLSKAIHKS FLEVNEEGSEAAAVSGMIAI SRMAVLYPQVIVDHPFFFLI RNRRTGTILFMGRVMHPETM NTSGHDFEEL |
| Tissue Specificity | Detected in brain cortex and hippocampus pyramidal neurons (at protein level). Detected in cerebrospinal fluid (at protein level). Predominantly expressed in the brain. |
| Function | Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable). |
| Protein Name | NeuroserpinPeptidase Inhibitor 12Pi-12Serpin I1 |
| Cellular Localisation | SecretedCytoplasmic VesicleSecretory Vesicle LumenPerikaryon |
| Alternative Antibody Names | Anti-Neuroserpin antibodyAnti-Peptidase Inhibitor 12 antibodyAnti-Pi-12 antibodyAnti-Serpin I1 antibodyAnti-SERPINI1 antibodyAnti-PI12 antibody |
Information sourced from Uniprot.org