| Tissue Specificity | Expressed predominantly in liver. Also present in plasma. Isoform 2: Expressed in plasma (at protein level). Expressed in liver. |
| Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
| Function | Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. Isoform 2: Shows negligible inhibition, in vitro, of thrombin and tPA and no inhibition of factor Xa, in vitro. |
| Protein Name | Heparin Cofactor 2Heparin Cofactor IiHc-IiProtease Inhibitor Leuserpin-2Hls2Serpin D1 |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-140875Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Alternative Antibody Names | Anti-Heparin Cofactor 2 antibodyAnti-Heparin Cofactor Ii antibodyAnti-Hc-Ii antibodyAnti-Protease Inhibitor Leuserpin-2 antibodyAnti-Hls2 antibodyAnti-Serpin D1 antibodyAnti-SERPIND1 antibodyAnti-HCF2 antibody |
Information sourced from Uniprot.org
