| Function | Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in HIV-1 surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to changes in HIV-1 Env conformation and loss of infectivity. Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes. |
| Protein Name | Serine Incorporator 5 |
| Database Links | Reactome: R-HSA-977347 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmPerinuclear Region(Microbial Infection) Upon Hiv-1 InfectionIt Is Redirected To Perinuclear Region Following Interaction With Hiv-1 NefExcluding It From Virions ParticlesThereby Preventing Subsequent Antiviral Defense ActivityLocalizes To The Cell MembraneWhere It Is Efficiently Incorporated Into Budding Virions And Impairs Subsequent Virion Entry Into Target Cells |
| Alternative Antibody Names | Anti-Serine Incorporator 5 antibodyAnti-SERINC5 antibodyAnti-C5orf12 antibody |
Information sourced from Uniprot.org
