| Tissue Specificity | Highly expressed in reproductive organs, such as testis, ovary and prostate. |
| Function | Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. |
| Protein Name | Sentrin-Specific Protease 6Sumo-1-Specific Protease 1Sentrin/Sumo-Specific Protease Senp6 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Sentrin-Specific Protease 6 antibodyAnti-Sumo-1-Specific Protease 1 antibodyAnti-Sentrin/Sumo-Specific Protease Senp6 antibodyAnti-SENP6 antibodyAnti-KIAA0797 antibodyAnti-SSP1 antibodyAnti-SUSP1 antibodyAnti-FKSG6 antibody |
Information sourced from Uniprot.org
