| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SENP3 (225-574) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SENP3 |
| Gene ID: |
26168 |
| Uniprot ID: |
SENP3_HUMAN |
| Immunogen Region: |
225-574 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 225-574 of human SENP3 (NP_056485.2). |
| Immunogen Sequence: |
GLRWTPKSPLDPDSGLLSCT LPNGFGGQSGPEGERSLAPP DASILISNVCSIGDHVAQEL FQGSDLGMAEEAERPGEKAG QHSPLREEHVTCVQSILDEF LQTYGSLIPLSTDEVVEKLE DIFQQEFSTPSRKGLVLQLI QSYQRMPGNAMVRGFRVAYK RHVLTMDDLGTLYGQNWLND QVMNMYGDLVMDTVPEKVHF FNSFFYDKLRTKGYDGVKRW TKNVDIFNKELLLIPIHLE |
| Function | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex.the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Deconjugates SUMO2 from KAT5. |
| Protein Name | Sentrin-Specific Protease 3Sumo-1-Specific Protease 3Sentrin/Sumo-Specific Protease Senp3 |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolusNucleoplasmCytoplasmRedistributes Between The Nucleolus And The Nucleoplasm In Response To Mild Oxidative StressMainly Found In The NucleoplasmWith Low Levels Detected In The Cytoplasmic And Chromatin Fractions |
| Alternative Antibody Names | Anti-Sentrin-Specific Protease 3 antibodyAnti-Sumo-1-Specific Protease 3 antibodyAnti-Sentrin/Sumo-Specific Protease Senp3 antibodyAnti-SENP3 antibodyAnti-SSP3 antibodyAnti-SUSP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
