| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SEMA3E (536-775) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SEMA3E |
| Gene ID: |
9723 |
| Uniprot ID: |
SEM3E_HUMAN |
| Immunogen Region: |
536-775 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 536-775 of human SEMA3E (NP_036563.1). |
| Immunogen Sequence: |
YCAWDGISCSRYYPTGTHAK RRFRRQDVRHGNAAQQCFGQ QFVGDALDKTEEHLAYGIEN NSTLLECTPRSLQAKVIWFV QKGRETRKEEVKTDDRVVKM DLGLLFLRLHKSDAGTYFCQ TVEHSFVHTVRKITLEVVEE EKVEDMFNKDDEEDRHHRMP CPAQSSISQGAKPWYKEFLQ LIGYSNFQRVEEYCEKVWCT DRKRKKLKMSPSKWKYANPQ EKKLRSKPEHYRLPRHTLD |
| Function | Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation. |
| Protein Name | Semaphorin-3e |
| Database Links | Reactome: R-HSA-416700 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Semaphorin-3e antibodyAnti-SEMA3E antibodyAnti-KIAA0331 antibodyAnti-SEMAH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
