| Function | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Mediates the recruitment of MIA3/TANGO to ERES. Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane. Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183. Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes. |
| Protein Name | Protein Transport Protein Sec16aSec16 Homolog AP250 |
| Database Links | Reactome: R-HSA-204005 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinGolgi Apparatus MembraneCytoplasmPerinuclear RegionCytosolMicrosome MembraneSar1a Activity Is Required To Maintain Sec16a Localization At Discrete Locations On The Er Membrane Perhaps By Preventing Its DissociationLocalizes To Endoplasmic Reticulum Exit Sites (Eres)Also Known As Transitional Endoplasmic Reticulum (Ter)Mia3 And Lrrk2 Are Required For Its Proper Localization To EresRecruited To Microsomal Membrane In Sar1-Dependent Manner |
| Alternative Antibody Names | Anti-Protein Transport Protein Sec16a antibodyAnti-Sec16 Homolog A antibodyAnti-P250 antibodyAnti-SEC16A antibodyAnti-KIAA0310 antibodyAnti-SEC16 antibodyAnti-SEC16L antibody |
Information sourced from Uniprot.org
