| Function | Pore-forming subunit of Nav1.4, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Highly expressed in skeletal muscles, Nav1.4 generates the action potential crucial for muscle contraction. |
| Protein Name | Sodium Channel Protein Type 4 Subunit AlphaSkm1Sodium Channel Protein Skeletal Muscle Subunit AlphaSodium Channel Protein Type Iv Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.4 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 4 Subunit Alpha antibodyAnti-Skm1 antibodyAnti-Sodium Channel Protein Skeletal Muscle Subunit Alpha antibodyAnti-Sodium Channel Protein Type Iv Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.4 antibodyAnti-SCN4A antibody |
Information sourced from Uniprot.org
