| Post Translational Modifications | Ubiquitinated at Lys-454 and Lys-466. RNF145 triggers ubiquitination of SCAP, likely inhibiting SCAP-SREBP complex transport to the Golgi apparatus and the subsequent processing/maturation of SREBF2/SREBP2. |
| Function | Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain. |
| Protein Name | Sterol Regulatory Element-Binding Protein Cleavage-Activating ProteinScapSrebp Cleavage-Activating Protein |
| Database Links | Reactome: R-MMU-1655829 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneCytoplasmic VesicleCopii-Coated Vesicle MembraneMoves From The Endoplasmic Reticulum To The Golgi In The Absence Of SterolsRequires The Presence Of Spring For Proper Localization To Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Sterol Regulatory Element-Binding Protein Cleavage-Activating Protein antibodyAnti-Scap antibodyAnti-Srebp Cleavage-Activating Protein antibodyAnti-Scap antibodyAnti-Kiaa0199 antibody |
Information sourced from Uniprot.org
