| Tissue Specificity | Predominantly expressed in brain. |
| Post Translational Modifications | Phosphorylated on serine residues following nuclear translocation. Polyubiquitinated.polyubiquitination involves TRAF6. |
| Function | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. Signaling adapter which plays a role in neuronal differentiation. Involved in regulation of NGF-dependent neurite outgrowth. May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway. |
| Protein Name | Ap-4 Complex Accessory Subunit Rusc1New Molecule Containing Sh3 At The Carboxy-TerminusNescaRun And Sh3 Domain-Containing Protein 1 |
| Cellular Localisation | CytoplasmNucleusCytoskeletonCytoplasmic VesicleEarly EndosomePostsynaptic DensityGolgi ApparatusTranslocated To The Nuclear Envelope Upon Stimulation With NgfAssociated With Membranes And Microtubules |
| Alternative Antibody Names | Anti-Ap-4 Complex Accessory Subunit Rusc1 antibodyAnti-New Molecule Containing Sh3 At The Carboxy-Terminus antibodyAnti-Nesca antibodyAnti-Run And Sh3 Domain-Containing Protein 1 antibodyAnti-RUSC1 antibodyAnti-NESCA antibody |
Information sourced from Uniprot.org
