| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RTKN |
| Gene ID: | 6242 |
| Uniprot ID: | RTKN_HUMAN |
| Immunogen Region: | 254-513 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 254-513 of human RTKN (NP_001015056.1). |
| Immunogen Sequence: | PLCMTQPTASGTLRVQQAGE MQNWAQVHGVLKGTNLFCYR QPEDADTGEEPLLTIAVNKE TRVRAGELDQALGRPFTLSI SNQYGDDEVTHTLQTESREA LQSWMEALWQLFFDMSQWKQ CCDEIMKIETPAPRKPPQAL AKQGSLYHEMAIEPLDDIAA VTDILTQREGARLETPPPWL AMFTDQPALPNPCSPASVAP APDWTHPLPWGRPRTFSLDA VPPDHSPRARSVAPLPPQR |
| Tissue Specificity | Highly expressed in prostate, moderately in kidney, heart, brain, spleen, testis, placenta, small intestine, pancreas, skeletal muscle and peripheral blood leukocytes, and weakly in ovary, colon and thymus. Weakly expressed in all normal cell lines tested. Overexpressed in various cancer cell lines. |
| Function | Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. |
| Protein Name | Rhotekin |
| Database Links | Reactome: R-HSA-5666185Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106 |
| Alternative Antibody Names | Anti-Rhotekin antibodyAnti-RTKN antibodyAnti-RTKN1 antibody |
Information sourced from Uniprot.org