| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RRN3 |
| Gene ID: | 54700 |
| Uniprot ID: | RRN3_HUMAN |
| Immunogen Region: | 550-651 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 550-651 of human RRN3 (NP_060897.3). |
| Immunogen Sequence: | QICTNPLDTFFPFDPCVLKR SKKFIDPIYQVWEDMSAEEL QEFKKPMKKDIVEDEDDDFL KGEVPQNDTVIGITPSSFDT HFRSPSSSVGSPPVLYMQPS PL |
| Post Translational Modifications | Phosphorylation is required for participation in rDNA transcription. Phosphorylated at Thr-200 by MAPK9/JNK2, which abrogates initiation complex formation. |
| Function | Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC). |
| Protein Name | Rna Polymerase I-Specific Transcription Initiation Factor Rrn3Transcription Initiation Factor IaTif-Ia |
| Database Links | Reactome: R-HSA-73762Reactome: R-HSA-73772 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Rna Polymerase I-Specific Transcription Initiation Factor Rrn3 antibodyAnti-Transcription Initiation Factor Ia antibodyAnti-Tif-Ia antibodyAnti-RRN3 antibodyAnti-TIFIA antibody |
Information sourced from Uniprot.org