| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RRN3 (550-651) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RRN3 |
| Gene ID: |
54700 |
| Uniprot ID: |
RRN3_HUMAN |
| Immunogen Region: |
550-651 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 550-651 of human RRN3 (NP_060897.3). |
| Immunogen Sequence: |
QICTNPLDTFFPFDPCVLKR SKKFIDPIYQVWEDMSAEEL QEFKKPMKKDIVEDEDDDFL KGEVPQNDTVIGITPSSFDT HFRSPSSSVGSPPVLYMQPS PL |
| Post Translational Modifications | Phosphorylation is required for participation in rDNA transcription. Phosphorylated at Thr-200 by MAPK9/JNK2, which abrogates initiation complex formation. |
| Function | Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction. |
| Protein Name | Rna Polymerase I-Specific Transcription Initiation Factor Rrn3Transcription Initiation Factor IaTif-Ia |
| Database Links | Reactome: R-HSA-73762Reactome: R-HSA-73772 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Rna Polymerase I-Specific Transcription Initiation Factor Rrn3 antibodyAnti-Transcription Initiation Factor Ia antibodyAnti-Tif-Ia antibodyAnti-RRN3 antibodyAnti-TIFIA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
