| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RPGRIP1L (1-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RPGRIP1L |
| Gene ID: |
23322 |
| Uniprot ID: |
FTM_HUMAN |
| Immunogen Region: |
1-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human RPGRIP1L (NP_056087.2). |
| Immunogen Sequence: |
MSGPTDETAGDLPVKDTGLN LFGMGGLQETSTTRTMKSRQ AVSRVSREELEDRFLRLHDE NILLKQHARKQEDKIKRMAT KLIRLVNDKKRYERVGGGPK RLGRDVEMEEMIEQLQEKVH ELEKQNETLKNRLISAKQQL QTQGYRQTPYNNVQSRINTG RRKANENAGLQECPRKGIKF QDADVAETPHPMFTKYGNSL LEEARGEIRNLENVIQSQRG QIEELEHLAEILKTQLRRK |
| Tissue Specificity | Ubiquitously expressed with relatively high level of expression in hypothalamus and islet. During early development, expressed in multiple organs including brain, eye, forelimb and kidney. |
| Function | Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis. Involved in the organization of apical junctions.the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins. Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2. |
| Protein Name | Protein FantomNephrocystin-8Rpgr-Interacting Protein 1-Like ProteinRpgrip1-Like Protein |
| Database Links | Reactome: R-HSA-5610787Reactome: R-HSA-5620912 |
| Cellular Localisation | CytoplasmCytoskeletonCilium Basal BodyCilium AxonemeMicrotubule Organizing CenterCentrosomeCell JunctionTight JunctionIn Cultured Renal CellsIt Localizes Diffusely In The Cytoplasm ButAs Cells Approach ConfluenceIt Accumulates To Basolateral Tight JunctionsLocalizes To The Ciliary Transition Zone |
| Alternative Antibody Names | Anti-Protein Fantom antibodyAnti-Nephrocystin-8 antibodyAnti-Rpgr-Interacting Protein 1-Like Protein antibodyAnti-Rpgrip1-Like Protein antibodyAnti-RPGRIP1L antibodyAnti-FTM antibodyAnti-KIAA1005 antibodyAnti-NPHP8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
