| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ROS1 (1934-2232) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ROS1 |
| Gene ID: |
6098 |
| Uniprot ID: |
ROS1_HUMAN |
| Immunogen Region: |
1934-2232 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1934-2232 of human ROS1 (NP_002935.2?). |
| Immunogen Sequence: |
IENLPAFPREKLTLRLLLGS GAFGEVYEGTAVDILGVGSG EIKVAVKTLKKGSTDQEKIE FLKEAHLMSKFNHPNILKQL GVCLLNEPQYIILELMEGGD LLTYLRKARMATFYGPLLTL VDLVDLCVDISKGCVYLERM HFIHRDLAARNCLVSVKDYT SPRIVKIGDFGLARDIYKND YYRKRGEGLLPVRWMAPESL MDGIFTTQSDVWSFGILIWE ILTLGHQPYPAHSNLDVLN |
| Tissue Specificity | Expressed in brain. Expression is increased in primary gliomas. |
| Post Translational Modifications | Phosphorylated. Probably autophosphorylates. Phosphorylation at Tyr-2274 is required for the interaction with PTPN6 that mediates ROS1 dephosphorylation. Phosphorylation at Tyr-2274 stimulates the kinase activity and the activation of the ERK1 signaling cascade. Phosphorylation at Tyr-2274 and/or Tyr-2334 recruits PTPN11. |
| Function | Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. |
| Protein Name | Proto-Oncogene Tyrosine-Protein Kinase RosProto-Oncogene C-RosProto-Oncogene C-Ros-1Receptor Tyrosine Kinase C-Ros Oncogene 1C-Ros Receptor Tyrosine Kinase |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Proto-Oncogene Tyrosine-Protein Kinase Ros antibodyAnti-Proto-Oncogene C-Ros antibodyAnti-Proto-Oncogene C-Ros-1 antibodyAnti-Receptor Tyrosine Kinase C-Ros Oncogene 1 antibodyAnti-C-Ros Receptor Tyrosine Kinase antibodyAnti-ROS1 antibodyAnti-MCF3 antibodyAnti-ROS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
