| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ROBO3 |
| Gene ID: |
64221 |
| Uniprot ID: |
ROBO3_HUMAN |
| Immunogen Region: |
1237-1386 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1237-1386 of human ROBO3 (NP_071765.2). |
| Immunogen Sequence: |
EMTPPLQGPRARFRKKPKAL PYRRENSPGDLPPPPLPPPE EEASWALELRAAGSMSSLER ERSGERKAVQAVPLAAQRVL HPDEEAWLPYSRPSFLSRGQ GTSTCSTAGSNSSRGSSSSR GSRGPGRSRSRSQSRSQSQR PGQKRREEPR |
| Function | Receptor involved in axon guidance during development. Acts as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits SLIT repulsion, and facilitates Netrin-1/NTN1 attraction. In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1/ROBO2. Binding OF NELL2 to the receptor ROBO3 promotes oligomerization of ROBO3, resulting in the repulsion of commissural axons in the midline. ROBO3 also indirectly boosts axon attraction to NTN1 without interacting with NTN1 itself. |
| Protein Name | Roundabout Homolog 3Roundabout-Like Protein 3 |
| Database Links | Reactome: R-HSA-428542 Q96MS0-1Reactome: R-HSA-9010553 Q96MS0-1Reactome: R-HSA-9010642 Q96MS0-1 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Roundabout Homolog 3 antibodyAnti-Roundabout-Like Protein 3 antibodyAnti-ROBO3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
