| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RNF212 (1-297) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RNF212 |
| Gene ID: |
285498 |
| Uniprot ID: |
RN212_HUMAN |
| Immunogen Region: |
1-297 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-297 of human RNF212 (NP_001124506.1). |
| Immunogen Sequence: |
MANWVFCNRCFQPPHRTSCF SLTNCGHVYCDACLGKGKKN ECLICKAPCRTVLLSKHTDA DIQAFFMSIDSLCKKYSRET SQILEFQEKHRKRLLAFYRE KISRLEESLRKSVLQIEQLQ SMRSSQQTAFSTIKSSVSTK PHGCLLPPHSSAPDRLESME VDLSPSPIRKSEIAAGPARI SMISPPQDGRMGPHLTASFC FIPWLTLSKPPVPGECVISR GSPCFCIDVCPHWLLLLAF |
| Function | SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination. |
| Protein Name | Probable E3 Sumo-Protein Ligase Rnf212Probable E3 Sumo-Protein Transferase Rnf212Ring Finger Protein 212 |
| Cellular Localisation | NucleusChromosomeAssociates To The Synaptonemal ComplexLocalizes To A Minority Of Double-Strand Breaks (Dsbs) SitesMarks Crossover Sites During Midpachynema |
| Alternative Antibody Names | Anti-Probable E3 Sumo-Protein Ligase Rnf212 antibodyAnti-Probable E3 Sumo-Protein Transferase Rnf212 antibodyAnti-Ring Finger Protein 212 antibodyAnti-RNF212 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
