| Function | SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination. |
| Protein Name | Probable E3 Sumo-Protein Ligase Rnf212Probable E3 Sumo-Protein Transferase Rnf212Ring Finger Protein 212 |
| Cellular Localisation | NucleusChromosomeAssociates To The Synaptonemal ComplexLocalizes To A Minority Of Double-Strand Breaks (Dsbs) SitesMarks Crossover Sites During Midpachynema |
| Alternative Antibody Names | Anti-Probable E3 Sumo-Protein Ligase Rnf212 antibodyAnti-Probable E3 Sumo-Protein Transferase Rnf212 antibodyAnti-Ring Finger Protein 212 antibodyAnti-RNF212 antibody |
Information sourced from Uniprot.org
