| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase RNF170 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RNF170 |
| Gene ID: | 81790 |
| Uniprot ID: | RN170_HUMAN |
| Specificity: | This antibody detects endogenous levels of RNF170 at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human RNF170 |
| Function | E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. Selectively inhibits the TLR3-triggered innate immune response by promoting the 'Lys-48'-linked polyubiquitination and degradation of TLR3. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf170Putative Lag1-Interacting ProteinRing Finger Protein 170Ring-Type E3 Ubiquitin Transferase Rnf170 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf170 antibodyAnti-Putative Lag1-Interacting Protein antibodyAnti-Ring Finger Protein 170 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf170 antibodyAnti-RNF170 antibody |
Information sourced from Uniprot.org