| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RNF170 |
| Gene ID: |
81790 |
| Uniprot ID: |
RN170_HUMAN |
| Immunogen Region: |
46-120 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 46-120 of human RNF170 (NP_001153696.1). |
| Immunogen Sequence: |
RNVHQNIHPENQELVRVLRE QLQTEQDAPAATRQQFYTDM YCPICLHQASFPVETNCGHL FCGACIIAYWRYGSW |
| Tissue Specificity | Expressed in the spinal chord. |
| Function | E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. Selectively inhibits the TLR3-triggered innate immune response by promoting the 'Lys-48'-linked polyubiquitination and degradation of TLR3. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf170Putative Lag1-Interacting ProteinRing Finger Protein 170Ring-Type E3 Ubiquitin Transferase Rnf170 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf170 antibodyAnti-Putative Lag1-Interacting Protein antibodyAnti-Ring Finger Protein 170 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf170 antibodyAnti-RNF170 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
