• Western blot analysis of various lysates using Rnf170 Rabbit polyclonal antibody (STJ117390) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-Rnf170 antibody (1-200) (STJ117390)

SKU:
STJ117390

£112.50 - £524.50
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Rnf170
Gene ID: 77733
Uniprot ID: RN170_MOUSE
Immunogen Region: 1-200
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of mouse Rnf170 (NP_084241.1).
Immunogen Sequence: MQRYWRFQDNKIQDICFGVL GESWIQRPVMARYYSEGQSL QQDDSFIEGVSDQVLVAVVV SLALTATLLYALLRNVQQNI HPENQELVRVLREQFQTEQD VPAPARQQFYTEMYCPICLH QASFPVETNCGHLFCGSCII AYWRYGSWLGAISCPICRQT VTLLLTVFGEDDQSQDVIRL RQDVNDYNRRFSGQPRSIME
Function E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. Selectively inhibits the TLR3-triggered innate immune response by promoting the 'Lys-48'-linked polyubiquitination and degradation of TLR3.
Protein Name E3 Ubiquitin-Protein Ligase Rnf170
Ring Finger Protein 170
Ring-Type E3 Ubiquitin Transferase Rnf170
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-E3 Ubiquitin-Protein Ligase Rnf170 antibody
Anti-Ring Finger Protein 170 antibody
Anti-Ring-Type E3 Ubiquitin Transferase Rnf170 antibody
Anti-Rnf170 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance