| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RASGRP2 (1-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RASGRP2 |
| Gene ID: |
10235 |
| Uniprot ID: |
GRP2_HUMAN |
| Immunogen Region: |
1-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RASGRP2 (NP_722541.1). |
| Immunogen Sequence: |
MAGTLDLDKGCTVEELLRGC IEAFDDSGKVRDPQLVRMFL MMHPWYIPSSQLAAKLLHIY QQSRKDNSNSLQVKTCHLVR YWISAFPAEFDLNPELAEQI KELKALLDQEGNRRHSSLID IDSVPTYKWKRQVTQRNPVG QKKRKMSLLFDHLEPMELAE HLTYLEYRSFCKILFQDYHS FVTHGCTVDNPVLERFISLF |
| Tissue Specificity | Detected in platelets, neutrophils and T lymphocytes (at protein level). Expressed in brain where it is enriched in the striatum. Also expressed in the hematopoietic system. Detected in heart, brain, lung, placenta, liver, skeletal muscle and kidney. |
| Post Translational Modifications | Isoform 2 is palmitoylated and myristoylated. |
| Function | Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. |
| Protein Name | Ras Guanyl-Releasing Protein 2Calcium And Dag-Regulated Guanine Nucleotide Exchange Factor ICaldag-GefiCdc25-Like ProteinHcdc25lF25b3.3 Kinase-Like Protein |
| Database Links | Reactome: R-HSA-114508Reactome: R-HSA-2871837Reactome: R-HSA-354192Reactome: R-HSA-392517 |
| Cellular Localisation | CytoplasmCytosolCell MembranePeripheral Membrane ProteinSynapseSynaptosomeCell ProjectionRuffle MembraneFound Both In The Cytosol And Associated With MembranesIsoform 2 Mainly Localizes To The Cell MembraneEnriched At Juxtamembrane Areas And Membrane Ruffles Through Association With F-ActinLocalizes To The Cell Bodies And Axons Of Striatal Neurons |
| Alternative Antibody Names | Anti-Ras Guanyl-Releasing Protein 2 antibodyAnti-Calcium And Dag-Regulated Guanine Nucleotide Exchange Factor I antibodyAnti-Caldag-Gefi antibodyAnti-Cdc25-Like Protein antibodyAnti-Hcdc25l antibodyAnti-F25b3.3 Kinase-Like Protein antibodyAnti-RASGRP2 antibodyAnti-CDC25L antibodyAnti-MCG7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
