| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase RNF144A (151-200 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RNF144A |
| Gene ID: |
9781 |
| Uniprot ID: |
R144A_HUMAN |
| Immunogen Region: |
151-200 aa |
| Specificity: |
UBCE7IP4 Polyclonal Antibody detects endogenous levels of UBCE7IP4 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human RNF144A at the amino acid range 151-200 |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC during DNA damage. Positively regulates DNA virus or exogenous cytosolic DNA-triggered innate immune response by mediating STING1 ubiquitination and increasing its 'Lys-6'-linked ubiquitination and translocation from the endoplasmic reticulum to the Golgi leading to downstream signaling pathways. Plays a positive role in EGF-dependent cell proliferation by prolonging EGF/EGFR signaling during EGF stimulation through EGFR ubiquitination. Increases ERK activity independently of EGFR signaling by promoting polyubiquitination and subsequent degradation of VRK3 in the cytosol. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf144aRing Finger Protein 144aUbcm4-Interacting Protein 4Ubiquitin-Conjugating Enzyme 7-Interacting Protein 4 |
| Database Links | Reactome: R-HSA-8866654 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinCytoplasmic Vesicle MembraneEndosome MembraneEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf144a antibodyAnti-Ring Finger Protein 144a antibodyAnti-Ubcm4-Interacting Protein 4 antibodyAnti-Ubiquitin-Conjugating Enzyme 7-Interacting Protein 4 antibodyAnti-RNF144A antibodyAnti-KIAA0161 antibodyAnti-RNF144 antibodyAnti-UBCE7IP4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
