| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RNASEH2B |
| Gene ID: | 79621 |
| Uniprot ID: | RNH2B_HUMAN |
| Immunogen Region: | 1-290 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human RNASEH2B (NP_078846.2). |
| Immunogen Sequence: | MAAGVDCGDGVGARQHVFLV SEYLKDASKKMKNGLMFVKL VNPCSGEGAIYLFNMCLQQL FEVKVFKEKHHSWFINQSVQ SGGLLHFATPVDPLFLLLHY LIKADKEGKFQPLDQVVVDN VFPNCILLLKLPGLEKLLHH VTEEKGNPEIDNKKYYKYSK EKTLKWLEKKVNQTVAALKT NNVNVSSRVQSTAFFSGDQA STDKEEDYIRYAHGLISDYI PKELSDDLSKYLKLPEPSA |
| Tissue Specificity | Widely expressed. |
| Function | Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. |
| Protein Name | Ribonuclease H2 Subunit BRnase H2 Subunit BAicardi-Goutieres Syndrome 2 ProteinAgs2Deleted In Lymphocytic Leukemia 8Ribonuclease Hi Subunit B |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Ribonuclease H2 Subunit B antibodyAnti-Rnase H2 Subunit B antibodyAnti-Aicardi-Goutieres Syndrome 2 Protein antibodyAnti-Ags2 antibodyAnti-Deleted In Lymphocytic Leukemia 8 antibodyAnti-Ribonuclease Hi Subunit B antibodyAnti-RNASEH2B antibodyAnti-DLEU8 antibody |
Information sourced from Uniprot.org