| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RIOK3 (200-519) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RIOK3 |
| Gene ID: |
8780 |
| Uniprot ID: |
RIOK3_HUMAN |
| Immunogen Region: |
200-519 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 200-519 of human RIOK3 (NP_003822.2). |
| Immunogen Sequence: |
NHVFNALKQHAYSEERRSAR LHEKKEHSTAEKAVDPKTRL LMYKMVNSGMLETITGCIST GKESVVFHAYGGSMEDEKED SKVIPTECAIKVFKTTLNEF KNRDKYIKDDFRFKDRFSKL NPRKIIRMWAEKEMHNLARM QRAGIPCPTVVLLKKHILVM SFIGHDQVPAPKLKEVKLNS EEMKEAYYQTLHLMRQLYHE CTLVHADLSEYNMLWHAGKV WLIDVSQSVEPTHPHGLEF |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Autophosphorylated (in vitro). |
| Function | Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA. |
| Protein Name | Serine/Threonine-Protein Kinase Rio3Rio Kinase 3Sudd Homolog |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Rio3 antibodyAnti-Rio Kinase 3 antibodyAnti-Sudd Homolog antibodyAnti-RIOK3 antibodyAnti-SUDD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
