Anti-Recombinant-WAPL antibody [RM2RM14] (STJA0026473)

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STJA0026473
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Host: Rabbit
Applications: IF/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Wings Apart-Like Protein Homolog is suitable for use in Immunofluorescence, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2RM14
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IF: 1:50-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: WAPL
Gene ID: 23063
Uniprot ID: WAPL_HUMAN
Post Translational Modifications Deubiquitinated by USP37.leading to stabilization.
Function Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Protein Name Wings Apart-Like Protein Homolog
Friend Of Ebna2 Protein
Wapl Cohesin Release Factor
Database Links Reactome: R-HSA-2467813
Reactome: R-HSA-2468052
Reactome: R-HSA-2470946
Reactome: R-HSA-2500257
Cellular Localisation Isoform 2: Nucleus
Nucleus
Chromosome
Cytoplasm
Associates With Chromatin Through The Cohesin Complex During Interphase
Released In The Cytoplasm From Nuclear Envelope Breakdown Until Anaphase
It Reaccumulates In Nucleus At Telophase
Alternative Antibody Names Anti-Wings Apart-Like Protein Homolog antibody
Anti-Friend Of Ebna2 Protein antibody
Anti-Wapl Cohesin Release Factor antibody
Anti-WAPL antibody
Anti-FOE antibody
Anti-KIAA0261 antibody
Anti-WAPAL antibody

Information sourced from Uniprot.org

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